University of Calgary
Functional MR Imaging
| The interpretation of functional MR imaging results is strongly dependent on the task patients are asked to perform in the MR scanner as well as patient effort. Sometime patients are too ill, too fatigued, or too immobile to be able to perform tasks well. This is problematic for clinical research applications of fMRI. Our fMRI program is investigating ways to study the synchrony between brain regions while the patient is at rest (that is, no tasks!) as a means to assess the integrity of brain networks in the presence of neurological disease. The primary goal of our research is to advance resting-state fMRI as a biomarker of disease diagnosis, prognosis, and treatment efficacy. |  Click to enlarge. |
Investigators:
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Fiona Costello, MD |
Mayank Goyal, MD |
Key Publications:
Crockford D, Goodyear BG, Edwards JD, Tavares H, Quickfall J, el-Guebaly N. Functional magnetic resonance imaging of pathological gamblers. Biol Psychiatry 2005; 58: 787-95
Pexman PM, Hargreaves IS, Edwards JD, Henry LC, Goodyear BG. The neural consequences of semantic richness: when more comes to mind, less activation is observed. Psychol Sci 2007; 18: 401-6.
Lau RWM,Goodyear BG. Minimum detectable change in water diffusion using 3 Tesla magnetic resonance imaging. Neuroimage 2007; 36: 491-6.
Goodyear BG, Douglas EA. Minimum detectable change in motor and prefrontal cortex activity over repeated sessions using 3 Tesla functional MRI and a block design. J Magn Reson Imaging 2008; 28: 1055-60.
Cunningham CJB, Zaamout MF, Goodyear BG, Federico P. Simultaneous EEG-fMRI in human epilepsy. Can J Neurol Sci 2008; 35: 420-35.
Goodyear BG, Douglas EA. Decreasing task-related brain activity over repeated functional MRI sessions for simple motor and cognitive tasks: implications for serial investigations. Exp Brain Res 2009; 192: 231-9.